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Epidiolex, the first cannabis-based medication approved by the US Food and Drug Administration, is now available by prescription in all 50 states.
The twice-daily oral solution is approved for use in patients 2 and older to treat two types of epileptic syndromes: Dravet syndrome, a rare genetic dysfunction of the brain that begins in the first year of life, and Lennox-Gastaut syndrome, a form of epilepsy with multiple types of seizures that begins in early childhood, usually between ages 3 and 5.
“Because these patients have historically not responded well to available seizure medications, there has been a dire need for new therapies that aim to reduce the frequency and impact of seizures,” said Justin Gover, CEO of GW Pharmaceuticals, the maker of Epidiolex, in a written statement. “We are committed to ensuring that these patients can access this novel cannabinoid medicine that has been thoroughly studied in clinical trials, manufactured to assure quality and consistency, and is eligible to be covered by insurance for appropriate patients.”
Related Video: The quick hit history of medical marijuana 01:56
Epidiolex was recommended for approval by an advisory committee in April and approved by the FDA in June. In September, the US Department of Justice and the Drug Enforcement Administration classified Epidiolex as a Schedule V substance, clearing the final hurdle for it to be legally prescribed by doctors in the United States. (Marijuana and CBD remain Schedule I substances.)
“Adequate and well-controlled clinical studies supported Epidiolex’s approval, so prescribers can have confidence in the drug’s uniform strength and consistent delivery that support appropriate dosing needed for treating patients with these complex and serious epilepsy syndromes,” FDA Commissioner Dr. Scott Gottlieb said in a written statement. “The FDA will continue to support rigorous scientific research on the potential medical uses of marijuana-derived products and stand ready to work with product developers who are interested in bringing patients safe and effective, high quality products.”
Dr. Orrin Devinsky, director of the Comprehensive Epilepsy Center at NYU Langone Health, served as the lead investigator of two of three phase three clinical trials of Epidiolex.
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“In those syndromes, when [Epidiolex] was added to three other seizure [medications], on average, it reduced convulsive seizures — or ‘drop seizures’ — by about 25% to 28% compared to a placebo,” Devinsky said. “So I think it’s very important to recognize … that it clearly is effective, and this was statistically significant in all three of the large studies that we did, but by the same token, the effect was modest.
“There are some people who had dramatic improvements. Many had a modest improvement, and some had no improvement. So it’s not a miracle drug. It’s an effective drug, and I think its side effect profile is quite good compared to other seizure drugs that we have, but it’s not a miracle cure,” Devinsky said.
The most common side effects of Epidiolex, according to GW Pharmaceuticals, include sleepiness, decreased appetite, diarrhea and an increase in liver enzymes.

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Shauna Garris, a pharmacist, pharmacy clinical specialist and adjunct assistant professor at the University of North Carolina’s Eshelman School of Pharmacy, said the drug is effective and works somewhere between “fairly” and “very well.” She has not used Epidiolex in her own clinical practice and was not involved in the development of the drug but said she’s not sure it will live up to “all of the hype” that has surrounded it.
Still, she said the FDA’s approval of Epidiolex signals “validation of the science of cannabinoid medication.”
Related Article: Dr. Sanjay Gupta to Jeff Sessions: Medical marijuana could save many addicted to opioids
GW Pharmaceuticals says the average list price of Epidiolex is $32,500 a year. The company expects that the drug will be covered by most insurance plans and asserts that “this price is in line with other branded, FDA-approved anti-epileptic drugs (AEDs), such as Banzel, and access for eligible patients is expected to be similar to such AEDs for similar indications for LGS (e.g., Onfi and Banzel).”
It is also launching a patient support program “to help patients who have been prescribed Epidiolex gain access to therapy. The program offers patient/caregiver-focused education and resources to help lower out-of-pocket costs or provide product at no cost for eligible patients.”
Although Epidiolex is approved only for the treatment of two rare seizure disorders, doctors can now prescribe the medication “off-label” for other conditions. According to the US Department of Health and Human Services, this is both legal and common; one in five of all medications prescribed is for off-label use.

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Marijuana which comes in the form dried leaves, flowers, stems and seeds. buy weed online safe. The Marijuana plant is often referred to as the hemp plant.buy marijuana online safe.buy weed online. The fibers of the hemp plant are used for clothes, rope, and paper. The active ingredients of the hemp plant are the cannabinoids which contains chemicals that are used as the psychoactive drug people refer to commonly as Marijuana.buy weed online. The cannabinoids can slightly vary from plant to plant. Two popular breeds of cannabinoids in plants are cannabis sativa or cannabis indica.buy weed online. These plants grow in warm climates throughout the world. Marijuana is referred to by many names, some of which include cannabis, weed, pot, dope, ganja, dank, and herb. The psychoactive drug is used for various medical and recreational reasons. Variation in drug preparation and storage can greatly affect its level of potency.buy weed online. Marijuana can contain up to several hundred active chemicals. Of these many chemicals, tetrahydrocannabinol (THC) is the one credited as having the greatest effect on the user.buy cannabis online.buy weed online.

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Strains, or varied forms, of cannabis that are of the indica breed are known to cause a stronger “body-high.” Users describe this high as more of a “full-body sensation” with a “couch-lock” effect,buy weed online like having no desire to move from the comfortable position on the couch. buy weed online.

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Users and their partners also experience a variety of reactions to using marijuana during intercourse. Some claim that it fosters a greater bond between partners, stating that marijuana facilitates a more beautiful, open connection.buy weed online.buy weed online However, buy weed online.some partners find that under the influence of cannabis they tend to lose focus or internalize their thoughts.buy weed online safe.as a result, they tend to emotionally distance their partners instead of bring them closer.buy weed online Europe.buy weed online One reason that some people may report a heightened sense of sexuality is that marijuana often distorts users’ sense of time, thus creating the illusion of prolonged arousal and orgasm.buy weed online Australia. Furthermore,buy weed online some studies suggest that there is an association of marijuana use with increased rates of high risk sexual behavior and sexually transmitted infections.buy weed online. best place to buy weed online. buyThis is due to marijuana’s ability to decrease inhibitions and make users less likely to use protection during intercourse. When using marijuana,buy weed online consent for sexual activity may become unclear. Consent is seen a clear and enthusiastic “yes” and is especially important when drugs/intoxication are involved. It is advised to take precaution and use protection,buy weed online such as a condom, when engaging in any sexual activity and establish a clear and comfortable form of communication when using marijuana or any drug. buy marijuana online.buy weed online

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buy weed online.As mentioned above, marijuana has the ability to bring people closer together or farther apart, both physically and emotionally.buy vape pens online. The use of marijuana should be discussed openly and honestly between partners.buy weed online Communication is essential for the health of every relationship. If one is concerned that their partner is experiencing negative effects from marijuana, it is best that they communicate their concerns in a considerate manner. Each partner should come to a common understanding about the role that marijuana plays in their relationship and how it affects each partner in the relationship.buy vape pens online cheap and safe.For tips on communicating with your partner, check out this article on “Effective Communication.”online weed buy weed online

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Marijuana has the ability to affect both male and female fertility. However, since the drug is outlawed by most societies around the world, research on the effects of cannabis have been limited. buy weed online.However, there have been some studies conducted that produced noteworthy correlations between marijuana use and its impact on fertility as well as fetal development.buy weed online.buy weed online

A study conducted in 2015 by the Oxford University Press found that smoking marijuana more than once a week might lower a male’s sperm count by nearly a third.buy weed online. Specifically, the men who smoked marijuana more than once a week produced sperm counts that were 28% lower, on average, than those who smoked marijuana less frequently or not at all.buy weed online

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In 2003, a study from the University of Buffalo found that smoking marijuana could make sperm less fertile, even if the female is the one who is using the drug. When females smoke marijuana, their reproductive fluids or vaginal secretions may contain the chemicals from cannabis.buy weed online. The research suggests that when a female smokes or ingests marijuana,buy weed online the THC is then present in the vagina, oviduct, and the uterus.buy weed online Even if a male has not smoked but the female has, his sperm may enter her body, come in contact with the THC in her system, and subsequently be altered by the THC/sperm interaction. buy weed online

The Alcohol and Drug Abuse Institute of the University of Washington suggests that marijuana use by females may affect their fertility by disrupting their menstrual cycle,buy weed online. which may result in fewer eggs being released. Furthermore, they conclude that THC has the ability to cross through the placental barrier and secrete into the breast milk of nursing mothers. buy weed online. Therefore, it is suggested that any pregnant or breastfeeding mother refrain from using marijuana.buy weed online. Furthermore, research shows that there may be major effects on the development and maturation of the fetal brain if a female uses marijuana during pregnancy. While these findings are not conclusive, they do point out the risks of using marijuana and its impact on both male and female fertility. buy weed online.

The use of marijuana and its effects on the mind, body, sex, relationships, and health are unique to every individual.buy weed online.While some claim that marijuana has a positive effect on their lives, others feel as though it affects their lives negatively. buy weed online. It is recommended that you discuss marijuana use with your doctor before experimenting with it. They may have insight as to how it will affect you and your body based on your medical history.buy weed online. SexInfo Online does not endorse the use of illegal drugs but promotes safety during the use or experimentation of any substance.buy weed online

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During the 1980s, several studies considered pot’s effects on lovemaking. The results were all over the map, from strongly sex-inhibiting to strongly sex-enhancing. The best report, based on interviews with 97 adults in Kansas City, showed that “over two-thirds reported increased sexual pleasure and satisfaction with marijuana use. best place to buy marijuana online safely. About half of both sexes also reported increased sexual desire while using marijuana. Emotional closeness and physical enjoyment of snuggling were also enhanced.” But one-third said the drug was not sex-enhancing, and half reported no increase in desire. [Weller, RA and JA Halikas, “Marijuana Use and Sexual Behavior. buy weed online

 

That was pretty much where things stood for 20 years.buy weed online.Then, in 2003, Canadian researchers interviewed 104 Toronto adults about their reactions to marijuana. Did it increase libido? One-quarter said it “often” or “always” did, 40 percent said “sometimes,” and one-third said it “seldom” or “never” enhanced their sexual desire. About half called the drug sex-enhancing, but half said it was not. buy marijuana online. One-third said sexual enhancement was a key reason they used weed, but half said sex played little, if any, role in their use of the drug.buy weed online safe and cheap

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In 2008, another Canadian team interviewed 41 adults. where can i buy marijuana online safe . About half said marijuana boosted their libidos, increased sensitivity to touch, and enhanced erotic pleasure.buy weed online saf.  But half said it did not. [Osborne GB and C Fogel. “Understanding the Motivations for Recreational Marijuana Use Among Canadians. buy weed online safe withou prescripton.

This range of findings is pharmacologically unique. The sexual effects of every other mood-altering drug–alcohol, amphetamines, antidepressants, cocaine, narcotics–are well-documented, fairly consistent, and not particularly controversial.buy weed online without a medical card. But oddly, marijuana’s sexual effects are highly unpredictable, from strongly sex-inhibiting to strongly sex-enhancing. Those who call it sex-inhibiting typically report that it pulls them deep inside themselves, so far inward that they lose their sense of connection to their partners.where can i buy weed onine safe. Meanwhile those who call marijuana sex-enhancing usually say that it boosts desire, adds to enjoyment of sensual touch. buy weed online cheap. helps them feel closer to their partner, and enhances overall sexual pleasure and satisfaction.

Unfortunately, all three of studies I mentioned involved small numbers of participants (97, 104, and 41). where to buy weed online safe without a medical card. Let’s correct that. How does marijuana affect you sexually? Is it sex-inhibiting? Sex-neutral? Or sex-enhancing?

Although survey studies have found that many guys report sexual benefits of marijuana use, such as increased sexual stamina, it is difficult to know what to make of findings like this. While the conclusion that marijuana helps guys last longer in bed is tempting, place to buy weed online safe.best we cannot rule out the possibility that this drug simply alters men’s perception of time. In other words, sex might seem to last longer when you’re high, but the actual amount of time you spend having sex might not really be any different from when you’re sober.

In the hope of providing a more definitive answer, biomedical researchers have begun to conduct more controlled research looking at the effect marijuana has on erectile functioning. Their scientific efforts reveal that, rather than helping erections, weed could potentially hurt them.

Animal studies have found that cannabis has an inhibitory effect on certain receptors inside the erectile tissue of the penis. buy cannabis online without prescription.We don’t have parallel research showing the same thing in humans (at least not yet) because of ethical and legal difficulties in conducting the research, but the animal findings suggest that marijuana is more of a sexual inhibitor than it is a sexual enhancer.

However, there are a few caveats.buy weed online.For one thing, researchers have long argued that dosage is a very important consideration when looking at the effects of this drug, just like it is with alcohol. If you consume marijuana or alcohol in small quantities, the inhibitory effects on sexual performance tend to be pretty minimal.bu cannabis online uk.  In fact, you may actually experience an overall performance boost with low doses due to these drugs lowering inhibitions and stimulating desire.buy cannabis online with descrete delivery.

In contrast, when drugs like marijuana and alcohol are consumed in larger quantities, erectile and other sexual problems (e.g., difficultly reaching orgasm) become much more likely.buy weed online.Consistent with the idea that higher doses of cannabis may be problematic, research has found that the prevalence of erectile dysfunction is three times as high for daily marijuana smokers compared to those who don’t use it at all.buy cannabis online safe

Beyond dose, there are at least two other things to keep in mind.buy marijuana online First, marijuana is not just one thing. There are different strains of cannabis that can affect the body in very different ways. One strain (indica) tends to more relaxing, while the other (sativa) tends to be more stimulating. Researchers haven’t yet looked at whether these cannabis strains impact sexual functioning in different ways, but it is worth exploring.buy marijuana online cheap

How does marijuana affects your brain

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Substantial evidence from animal research and a growing number of studies in humans indicate that marijuana exposure during development can cause long-term or possibly permanent adverse changes in the brain. Rats exposed to THC before birth, soon after birth, or during adolescence show notable problems with specific learning and memory tasks later in life.32–34 Cognitive impairments in adult rats exposed to THC during adolescence are associated with structural and functional changes in the hippocampus.Studies in rats also show that adolescent exposure to THC is associated with an altered reward system, increasing the likelihood that an animal will self-administer other drugs (e.g., heroin) when given an opportunity (see “Is marijuana a gateway drug?”).

Imaging studies of marijuana’s impact on brain structure in humans have shown conflicting results. Some studies suggest regular marijuana use in adolescence is associated with altered connectivity and reduced volume of specific brain regions involved in a broad range of executive functions such as memory, learning, and impulse control compared to people who do not use.38,39 Other studies have not found significant structural differences between the brains of people who do and do not use the drug.40

Several studies, including two large longitudinal studies, suggest that marijuana use can cause functional impairment in cognitive abilities but that the degree and/or duration of the impairment depends on the age when a person began using and how much and how long he or she used.41

Among nearly 4,000 young adults in the Coronary Artery Risk Development in Young Adults study tracked over a 25-year period until mid-adulthood, cumulative lifetime exposure to marijuana was associated with lower scores on a test of verbal memory but did not affect other cognitive abilities such as processing speed or executive function. The effect was sizeable and significant even after eliminating those involved with current use and after adjusting for confounding factors such as demographic factors, other drug and alcohol use, and other psychiatric conditions such as depression.

A large longitudinal study in New Zealand found that persistent marijuana use disorder with frequent use starting in adolescence was associated with a loss of an average of 6 or up to 8 IQ points measured in mid-adulthood.43 Significantly, in that study, those who used marijuana heavily as teenagers and quit using as adults did not recover the lost IQ points. People who only began using marijuana heavily in adulthood did not lose IQ points. These results suggest that marijuana has its strongest long-term impact on young people whose brains are still busy building new connections and maturing in other ways. The endocannabinoid system is known to play an important role in the proper formation of synapses (the connections between neurons) during early brain development, and a similar role has been proposed for the refinement of neural connections during adolescence. If the long-term effects of marijuana use on cognitive functioning or IQ are upheld by future research, this may be one avenue by which marijuana use during adolescence produces its long-term effects.

However, recent results from two prospective longitudinal twin studies did not support a causal relationship between marijuana use and IQ loss. Those who used marijuana did show a significant decline in verbal ability (equivalent to 4 IQ points) and in general knowledge between the preteen years (ages 9 to 12, before use) and late adolescence/early adulthood (ages 17 to 20). However, at the start of the study, those who would use in the future already had lower scores on these measures than those who would not use in the future, and no predictable difference was found between twins when one used marijuana and one did not. This suggests that observed IQ declines, at least across adolescence, may be caused by shared familial factors (e.g., genetics, family environment), not by marijuana use itself.45 It should be noted, though, that these studies were shorter in duration than the New Zealand study and did not explore the impact of the dose of marijuana (i.e., heavy use) or the development of a cannabis use disorder; this may have masked a dose- or diagnosis-dependent effect.

The ability to draw definitive conclusions about marijuana’s long-term impact on the human brain from past studies is often limited by the fact that study participants use multiple substances, and there is often limited data about the participants’ health or mental functioning prior to the study. Over the next decade, the National Institutes of Health is funding the Adolescent Brain Cognitive Development (ABCD) study—a major longitudinal study that will track a large sample of young Americans from late childhood (before first use of drugs) to early adulthood. The study will use neuroimaging and other advanced tools to clarify precisely how and to what extent marijuana and other substances, alone and in combination, affect adolescent brain development.

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Cannabis oil is a concentrated extract obtained by extraction of the dried flowers or leaves of the cannabis plant. It is not actually an oil, but derives its name from its sticky and oily appearance. The purpose of producing cannabis oil is to make cannabinoids and other beneficial components, such as terpenes, available in a highly concentrated form.

Medicinal cannabis oil extracted from Bedrocan’s standardised products is currently only available in the Netherlands and Germany.

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Pharmacies in many countries where medicinal cannabis is regulated are permitted to compound oils from standardised cannabis plant material (cannabis flos). Patients must receive a prescription from their doctor in order to use oils which are to be dispensed and used for medicinal purposes.

Pharmaceutical companies producing oils are subject to a pharmaceutical production licence for controlled drugs, issued by government regulators. Currently there are no pharmaceutical companies producing cannabis oil as a medicine. This might change in the future when a standardised, GMP-certified production method becomes available, setting the standards for the production of cannabis oil as a pharmaceutical product.

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