First FDA-approved cannabis-based drug now available in the US

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Epidiolex, the first cannabis-based medication approved by the US Food and Drug Administration, is now available by prescription in all 50 states.
The twice-daily oral solution is approved for use in patients 2 and older to treat two types of epileptic syndromes: Dravet syndrome, a rare genetic dysfunction of the brain that begins in the first year of life, and Lennox-Gastaut syndrome, a form of epilepsy with multiple types of seizures that begins in early childhood, usually between ages 3 and 5.
“Because these patients have historically not responded well to available seizure medications, there has been a dire need for new therapies that aim to reduce the frequency and impact of seizures,” said Justin Gover, CEO of GW Pharmaceuticals, the maker of Epidiolex, in a written statement. “We are committed to ensuring that these patients can access this novel cannabinoid medicine that has been thoroughly studied in clinical trials, manufactured to assure quality and consistency, and is eligible to be covered by insurance for appropriate patients.”
Related Video: The quick hit history of medical marijuana 01:56
Epidiolex was recommended for approval by an advisory committee in April and approved by the FDA in June. In September, the US Department of Justice and the Drug Enforcement Administration classified Epidiolex as a Schedule V substance, clearing the final hurdle for it to be legally prescribed by doctors in the United States. (Marijuana and CBD remain Schedule I substances.)
“Adequate and well-controlled clinical studies supported Epidiolex’s approval, so prescribers can have confidence in the drug’s uniform strength and consistent delivery that support appropriate dosing needed for treating patients with these complex and serious epilepsy syndromes,” FDA Commissioner Dr. Scott Gottlieb said in a written statement. “The FDA will continue to support rigorous scientific research on the potential medical uses of marijuana-derived products and stand ready to work with product developers who are interested in bringing patients safe and effective, high quality products.”
Dr. Orrin Devinsky, director of the Comprehensive Epilepsy Center at NYU Langone Health, served as the lead investigator of two of three phase three clinical trials of Epidiolex.
Related Video: Your brain on marijuana 01:39
“In those syndromes, when [Epidiolex] was added to three other seizure [medications], on average, it reduced convulsive seizures — or ‘drop seizures’ — by about 25% to 28% compared to a placebo,” Devinsky said. “So I think it’s very important to recognize … that it clearly is effective, and this was statistically significant in all three of the large studies that we did, but by the same token, the effect was modest.
“There are some people who had dramatic improvements. Many had a modest improvement, and some had no improvement. So it’s not a miracle drug. It’s an effective drug, and I think its side effect profile is quite good compared to other seizure drugs that we have, but it’s not a miracle cure,” Devinsky said.
The most common side effects of Epidiolex, according to GW Pharmaceuticals, include sleepiness, decreased appetite, diarrhea and an increase in liver enzymes.

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Shauna Garris, a pharmacist, pharmacy clinical specialist and adjunct assistant professor at the University of North Carolina’s Eshelman School of Pharmacy, said the drug is effective and works somewhere between “fairly” and “very well.” She has not used Epidiolex in her own clinical practice and was not involved in the development of the drug but said she’s not sure it will live up to “all of the hype” that has surrounded it.
Still, she said the FDA’s approval of Epidiolex signals “validation of the science of cannabinoid medication.”
Related Article: Dr. Sanjay Gupta to Jeff Sessions: Medical marijuana could save many addicted to opioids
GW Pharmaceuticals says the average list price of Epidiolex is $32,500 a year. The company expects that the drug will be covered by most insurance plans and asserts that “this price is in line with other branded, FDA-approved anti-epileptic drugs (AEDs), such as Banzel, and access for eligible patients is expected to be similar to such AEDs for similar indications for LGS (e.g., Onfi and Banzel).”
It is also launching a patient support program “to help patients who have been prescribed Epidiolex gain access to therapy. The program offers patient/caregiver-focused education and resources to help lower out-of-pocket costs or provide product at no cost for eligible patients.”
Although Epidiolex is approved only for the treatment of two rare seizure disorders, doctors can now prescribe the medication “off-label” for other conditions. According to the US Department of Health and Human Services, this is both legal and common; one in five of all medications prescribed is for off-label use.

Cannabis VS Brain cancer

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What is cannabis?

You have probably come across many names for cannabis, including marijuana, hemp, pot, grass and hash. Cannabis has been used by people for thousands of years, both medicinally and recreationally.best place to buy cannabis online

The cannabis plant produces a resin that contains various substances. Some of these may have medicinal value. These substances are known as cannabinoids.

Two main cannabinoids have been identified:

  • delta-9-tetrahydrocannabidiol (THC) – it is illegal to use this substance in the UK
  • cannabidiol (CBD) – CBD is legal in the UK.

There are some drugs available that are derived from cannabis, for example Sativex, used for multiple sclerosis and Nabilone, used sometimes for sickness caused by chemotherapy. These go through the same processes as any other medicine to be licensed in the UK as a prescribable drug.best place to buy marijuana  online

 

Cannabis oil

Cannabis, particularly cannabis oil, is a popular topic. Understandably, many people want to try anything that may help treat their own, or a loved one’s, cancer – particularly if things aren’t going well with conventional treatments. Cannabis oil is only one of a number of treatments people might come across. Cannabis oil can contain varying amounts of CBD and THC.

If you are thinking about using cannabis oil, there are some important things to keep in mind:

  • Buying it online can be risky. One reason for this is because you don’t know what you are getting, for example how pure it is. that is why topmedicalstore is here for you to provide you with the best of quality. we are the best place to buy cannabis online
  • There are side effects of using cannabis oil. THC can increase your heart rate, cause dizziness, hallucinations, paranoia and make you feel ‘stoned’. They may also interact with other drugs.
  • The cannabinoid delta-9-tetrahydrocannabidiol (THC) and products that contain THC are illegal in the UK.

CBD oil

CBD in its pure form is not a controlled substance under the Misuse of Drugs Act.

CBD oil does not contain THC and therefore does not have any psychoactive effects. It can be sold in the UK as long as it is sold as a food supplement and the sellers are not making any claim about its medicinal properties.

There are a number of examples where people say that using CBD oil has had a dramatic effect on their health. But these are individual stories and not based on clinical research trials. If you are thinking of using CBD oil, we suggest you talk to your healthcare team.best place to buy cannabis online 

Cannabis and cancer

The cannabis plant (also known as the hemp plant) has been used in just about every culture for centuries. In fact, cannabis is included in the 50 fundamental herbs within the cornucopia of Traditional Chinese Medicine. It has been cited in ancient texts as having a healing effect on over 100 ailments. In recent years in the United States, the collective mood is changing in regards to cannabis/hemp (aka “marijuana”).

Cannabis and cannabinoids – what are they?

Cannabis has lots of names, including marijuana, pot, grass, weed, hemp, hashish or dope. Hemp oil is made from the seeds of a type of cannabis plant that doesn’t contain the main psychoactive ingredient, called delta-9 tetrahydrocannabinol (THC).

Cannabinoids” is a blanket term covering a family of complex chemicals (both natural and man-made) that lock on to molecules on the surface of cells called cannabinoid receptors.buy weed online safe

The human body also creates its own cannabinoid chemicals, known as endocannabinoids. Endocannabinoids, and the molecules they attach to (cannabinoid receptors), are involved in many systems and processes throughout the body, from appetite to the sensation of pain. Because of this molecular multitasking, they’re also linked to a huge range of illnesses, from cancer to neurodegenerative diseases.best place to buy cannabis online

Through many detailed experiments, summarised in this Nature Reviews Cancer article, scientists have discovered that both natural and synthetic cannabinoids have a wide range of effects on cells.

Personally, I prefer to use the term “hemp” or “cannabis” since those are proper names for the plant, and the truth is that the term “marijuana” (derived from the Mexican slang “marihuana”) was popularized in the early 1930s by the Federal Bureau of Narcotics (which later became the DEA) in order to make this amazing plant sound sinister and to elude the public’s existing familiarity and comfort level with the plant and the medical application of cannabis/hemp tinctures. “Marijuana” was not a commonly smoked recreational drug at the time.best place to buy cannabis online

Currently there are 25 states where it is legal for patients to use “marijuana” for medical purposes. Pending federal legislation may open up opportunities for federally-funded medical research, including human clinical trials. This will further prove cannabis’ track-record when it comes to healing a number of disease conditions − including cancer.buy weed online safe

Can cannabinoids treat cancer?

Many hundreds of scientific papers looking at cannabinoids and cancer have been published, but these studies simply haven’t found enough robust scientific evidence to prove that these can safely and effectively treat cancer.

Research is still ongoing though, with hundreds of scientists investigating the potential of cannabinoids in cancer and other diseases as part of The International Cannabinoid Research Society. And in 2015 the scientific journal Nature published a supplement of review articles about various aspects of cannabis. It’s free to access.best place to buy cannabis online

Claims that there is solid “proof” that cannabis or cannabinoids can cure cancer is highly misleading to patients and their families, and builds a false picture of the state of progress in this area.best place to buy cannabis online

A researcher with some cells in a Petri dishThis is because virtually all the scientific research investigating whether cannabinoids can treat cancer has been done using cancer cells grown in the lab or animals. Because humans are much more complex, these studies don’t necessarily hold true for people. That’s why so many promising results in the lab sadly don’t translate into safe or effective treatments when tested in humans.best place to buy cannabis online

So far, the best results from lab studies have come from using a combination of highly purified THC and cannabidiol (CBD), a cannabinoid found in cannabis plants that counteracts the psychoactive effects of THC. But researchers have also found positive results using man-made cannabinoids, such as a molecule called JWH-133.best place to buy cannabis online

There have been intriguing results from lab experiments looking at a number of different cancers, including glioblastoma brain tumours, prostate, breast, lung, and pancreatic cancers. But the take-home message is that different cannabinoids seem to have different effects on various cancer types, so they are far from being a ‘universal’ treatment.buy weed online safe

buy weed online safe.There’s also evidence that cannabinoids have unwanted effects. Although high doses of THC can kill cancer cells, they also harm crucial blood vessel cells. And under some circumstances, cannabinoids can encourage cancer cells to grow, or have different effects depending on the dose used and levels of cannabinoid receptors present on the cancer cells.

Cannabis in clinical trials

To robustly test the potential benefits of cannabinoids in cancer, clinical trials in large numbers of people with control groups of patients – who aren’t given the treatment in question – would be needed.buy weed online safe

Results have been published from only one small clinical trial testing whether cannabinoids can treat cancer in patients, led by Dr Manuel Guzman and his team in Spain. Nine people with advanced, incurable glioblastoma multiforme – the most aggressive brain tumour – were given highly purified THC through a tube directly into their brain.

This study showed that THC given in this way is safe and doesn’t seem to cause significant side effects, which suggests that cannabinoids could be worth pursuing in further clinical trials. But because this was an early stage trial without a control group, it couldn’t show whether THC helped to extend patients’ lives.best place to buy cannabis online

A handful of other clinical trials of cannabinoids for cancer are being set up. We’re helping to support the only two UK trials of cannabinoids for treating cancer, through our Experimental Cancer Medicine Centre (ECMC) Network. Both are at very early stages. One is testing a man-made cannabinoid called dexanabinol in patients with different types of advanced cancer. The second is testing whether Sativex (nabiximols), a highly purified pharmaceutical-grade extract of cannabis containing THC and CBD, can treat people with glioblastoma multiforme brain tumours that have come back after treatment.buy weed online safe

Results from the second trial have now been released. These showed that combining Sativex with the chemotherapy temozolomide increased the number of patients who were alive one year after their brain tumour came back from 53% to 83%. This was a small trial with 21 patients taking part, so larger clinical trials are needed to confirm what the benefits of Sativex might be, and which patients are most likely to respond to this combination of treatments.best place to buy cannabis online

“But it worked for this patient…”

Doctors sometimes publish case reports about extraordinary or important observations they have seen in their clinic. For example, there is a published case report of a 14-year old girl from Canada who was treated with cannabis extracts (also referred to as “hemp oil”). But very little reliable information can be taken from a single patient treated with what’s an unknown mix of cannabinoids outside of a controlled clinical setting.buy weed online safe

Dr Wai Liu at St George’s University is researching cannabis and cannabinoids for treating cancer (not funded by Cancer Research UK) to build up the evidence. He is happy to collect individual stories from UK patients and can be contacted by email. In the US, the Office of Cancer Complementary and Alternative Medicine gathers similar stories for their Best Case Series.buy weed online safe

Unanswered questions

There are still many unanswered questions around the potential for using cannabinoids to treat cancer. It’s not clear:

  • which type of cannabinoid – either natural or synthetic – might be most effective
  • what kind of doses might be needed
  • which types of cancer might respond best to cannabinoids
  • how to avoid the psychoactive effects of THC
  • how best to get cannabinoids, which don’t dissolve easily in water, into cancer cells
  • whether cannabinoids will help to boost or counteract the effects of chemotherapy

These questions must be answered for cannabinoids to be used as safe and effective treatments for cancer patients. It’s the same situation for the many hundreds of other potential cancer drugs being developed and tested in university, charity and industry labs all over the world. Without doing rigorous scientific research, we will never sift the ‘hits’ from the ‘misses’. If cannabinoids are to get into the clinic, these hurdles first need to be overcome and their benefits proven over existing cancer treatments.best place to buy cannabis online

Can cannabis prevent or cause cancer?

There is no reliable evidence that cannabis can prevent cancer. There has been some research suggesting that endocannabinoids (mentioned earlier) can suppress tumour growth, and in experiments where mice were given very high doses of purified THC, they seemed to have a lower risk of developing cancer. But this is not enough solid scientific evidence to suggest that cannabinoids or cannabis can cut people’s cancer risk.buy weed online safe

The evidence is a lot less clear when it comes to whether cannabis can cause cancer. This is because most people who use cannabis smoke it mixed with tobacco, a substance that we know causes cancer.

This complex issue hit the headlines in 2012 when the British Lung Foundation released a study suggesting that the cancer risks of cannabis had been underestimated, although this has been questioned by some experts, including Professor David Nutt.best place to buy cannabis online

What about controlling cancer symptoms such as pain or sickness?

There is good evidence that cannabinoids may be beneficial in managing cancer pain and side effects from treatment.

As far back as the 1980s, cannabinoid-based drugs including dronabinol (synthetic THC) and nabilone were used to help reduce nausea and vomiting caused by chemotherapy. But there are now safer and more effective alternatives and cannabinoids tend to only be used where other approaches fail.buy weed online safe

In some parts of the world, medical marijuana has been legalised for relieving pain and symptoms (palliative use), including cancer pain. But one of the problems with using herbal cannabis is managing the dose. Smoking cannabis or taking it in the form of tea often provides an inconsistent dose, which may make it difficult for patients to monitor their intake. So, researchers are turning to alternative dosing methods, such as mouth sprays, which deliver a reliable and regulated dose.

Large-scale clinical trials in the UK have been testing whether a mouth spray formulation of Sativex (nabiximols; mentioned earlier) can help to control severe cancer pain that doesn’t respond to other drugs. Results from these didn’t find any difference in self-reported pain scores between the treatment and the placebo.

Cannabinoids may also have potential in combating the loss of appetite and wasting (cachexia) experienced by some people with cancer, although so far clinical evidence is lacking. One clinical trial comparing appetite in groups of cancer patients given cannabis extract, THC and a placebo didn’t find a difference between the treatments, while another didn’t show any benefit and was closed early.best place to buy cannabis online

Is Cancer Research UK investigating cannabinoids?

Cancer Research UK has funded research into cannabinoids, notably the work of Professor Chris Paraskeva in Bristol investigating the properties of cannabinoids as part of his research into the prevention and treatment of bowel cancer. He has published a number of papers detailing lab experiments looking at endocannabinoids as well as THC, and written a review looking at the potential of cannabinoids for treating bowel cancer.

We also support the only two UK clinical trials of cannabinoids for treating cancer, mentioned above, through our national network of Experimental Cancer Medicine Centres.best place to buy cannabis online

buy weed online safe. Our funding committees have previously received other applications from researchers who want to investigate cannabinoids but these failed to reach our high standards for funding. If we receive future proposals that meet these stringent requirements, then there is no reason that they wouldn’t be funded, assuming we have the money available.

Unfortunately, some scammers are using the email address ukcancerresearchcentre@gmail.com and claiming to be based at our head office, tricking cancer patients and their families into handing over money for “cannabis oil”, after which they receive nothing in return. This is a scam and has nothing to do with Cancer Research UK or our employees. If you believe you have been a victim of this fraud, please contact the police.buy weed online safe here we recommend them for they are legit.

“It’s natural so it must be better, right?”

There’s no doubt that the natural world is a treasure trove of biologically useful compounds, and there are countless examples where these have been harnessed as effective treatments.

Numerous potent cancer drugs have also been developed in this way – purifying a natural compound, improving it and testing it to create a beneficial drug – including taxol, vincristine, vinblastine, camptothecin, colchicine, and etoposide. But although these purified drugs in controlled high doses can treat cancer, it doesn’t mean that the original plant (or a simple extract) will have the same effect. So, although cannabis contains certain cannabinoids, it doesn’t automatically follow that cannabis itself can treat cancer.best place to buy cannabis online

“Have you seen this video? This guy says cannabis cures cancer!”

There are many videos and anecdotes online claiming that people have been completely cured of cancer with cannabis, hemp/cannabis oil or other cannabis derivatives.

Despite what these sources may claim, it’s impossible to tell whether these patients have been ‘cured’ by cannabis or not. There is usually no information about their medical diagnosis, stage of disease, what other cancer treatments they had, or the chemical make-up of their treatment. These sources also only publish the “success stories”, and don’t share how many people who used cannabis or its derivatives had no benefit, or worse, were potentially harmed.

Robust scientific studies describe the detail of experiments and share the results – positive or negative. This is vital for working out whether a potential cancer treatment is truly safe and effective, or not. And publishing this data allows doctors around the world to judge the information for themselves and use it for the benefit and safety of their patients.

This is the standard to which all cancer treatments are held, and it’s one that cannabinoids should be held to, too.best place to buy cannabis online

Cannabis and The Endocannabinoid System

In the mid-1990s, renowned Israeli researcher Dr. Ralph Mechaoulam, professor of Medicinal Chemistry at Hebrew University in Jerusalem, made an exciting discovery that would forever change how we look at our biological relationship to plant medicine. Dr. Mechaoulam discovered a subtle system within the body that seemed to have a balancing effect on every other system. He called it the Endocannabinoid (EC) System and it can be found in all mammals, including humans.

The EC system consists of a series of molecular receptors that are designed to receive cannabinoids. In particular this includes cannabidiol (CBD) and tetrahydrocannabinol (THC) as well as other related substances such as cannabigerol (CBG) and cannabinol (CBN).best place to buy cannabis online

Prior research in the 1980s led Mechaoulam and others to pinpoint two main receptors for cannabinoids − cannabinoid 1 (CB1) and cannabinoid 2 (CB2). Researchers at the time also defined the natural substances called endocannabinoids, which our body produces on its own in a similar way it produces endorphins. Phytocannabinoids (namely THC, CBD, and their variants), on the other hand, come directly from the cannabis plant.

Cannabinoid receptors CB1 and CB2 are designed by the body to be specific targets for THC, while our natural endocannabinoids help to synthesize it. The process of THC-cannabinoid receptor binding and what this does for the body is what researchers have been studying for over two decades. They are doing this in order to find out exactly how cannabis works in healing cancer.

Microbiologist Dr. Christine Sanchez of Compultense Univeristy in Madrid, Spain has been studying cannabinoids and cancer since the early 2000s. She was the first to discover the antitumor effects of cannabinoids.

“We now know that the endocannabinoid system regulates a lot of biological functions such as appetite, food intake, motor function, reproduction and many others and that is why the plant has such a wide therapeutic potential,” says Dr. Sanchez in a video interview for the web-based cable channel Cannabis Planet.buy weed online safe

Cannabis and Cancer Tumor Growth

“We observed that when we treated [astrocytoma, a type of brain tumor] cells with cannabinoids, the THC…was killing the cells in our Petri dishes,” Dr. Sanchez says. “We…decided to analyze these components in animal models of breast and brain tumors. The results we are obtaining are telling us that cannabinoids may be useful for the treatment of Breast Cancer.”buy weed online safe

Sanchez and other researchers have confirmed that the most potent effects against tumor growth occur when THC and CBD are combined.

Cannabidiol, or CBD, which does not have a psychoactive effect, has long been known as a potent anti-cancer agent. This is because of its ability to interfere with cellular communication in tumors as well as in its ability to instigate apoptosis, or programmed cancer cell death. Some research studies, including in vitro and animal-based trials conducted by San Francisco-based researchers at the California Pacific Medical Center, have also shown that CBD may affect genes involved in aggressive metastasis. It does this by helping to shut down cellular growth receptors.

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Δ9-Tetrahydrocannabinol (i.e. THC), the psychoactive counterpart to CBD, has been shown to reduce tumor growth as well. It has also shown to have an effect on the rate of metastasis, including for non-small cell lung cancer − the leading cause of cancer deaths globally. A 2007 study on THC and highly-aggressive epidermal growth factor receptor-overexpressing (EGF-expressing) lung cancer conducted by Harvard Medical School found that certain EGF lung cancer cells express CB1 and CB2 cannabinoid receptors. They found that the presence of THC effected metastasis of these cells by reducing the “focal adhesion complex,” which plays a vital role in cancer migration.best place to buy cannabis online

Studies have also been conducted on the combined effect of CBD and THC on lung, prostate, colon, pancreatic, liver, bladder, cervical, blood-based, brain, and other forms of cancer. These studies lend increasing evidence to the fact that cannabinoids are not only antioxidant phytonutrients but powerful “herbal chemo” agents.

Says Dr. Sanchez: “One of the advantages of cannabinoid-based medicines would be that they target specifically tumor cells. They don’t have any toxic effect on normal non-tumoral cells. This is an advantage with respect to standard chemotherapy that targets basically everything.”buy weed online safe

If You Use Cannabis for Cancer, Do it Right

Because cannabinoid therapy is relatively new in the mainstream, a current challenge for patients regarding its use is lack of regulation. This may change, however, with the possible passing of the Compassionate Access, Research Expansion, and Respect States (CARERS) Act, which has the support of 37 members of Congress.

CARERS would remove “marijuana” from the Controlled Substances Act Schedule I drug category, where it has been since 1970 − on par with heroin and cocaine. This classification is ridiculous since, by definition, Schedule I drugs have “no currently accepted medical uses” and the Department of Health and Human Services (HHS) holds a patent (U.S. Patent 6630507) on cannabis oil for medical use!buy weed online safe

Think about it. How can HHS hold a medical use patent for cannabis oil if there are no medical uses for cannabis? OK, enough of the logic lesson. Let’s just say that there are some serious logic deficiencies in these laws.buy weed online safe with overnight delivery

If “marijuana” is rightfully removed from a Schedule I drug, this would open the door for more targeted, federally-funded research as well as increased patient access to this amazing healing plant.best place to buy cannabis online

In the meantime, if you are on a cancer-healing path and are considering using cannabinoids, here are some general guidelines that experts agree are worth considering:buy weed online safe with overnight delivery

  1. Do your own research. The best way to learn about the power of cannabis in healing cancer is to start digging. There are approximately 500 articles on Pubmed alone relating to cannabis and cancer. Learn about strains, qualified targeted research studies, what method of administration may be right for you, and the importance of balancing the Endocannabinoid System.buy weed online safe with overnight delivery
  2. Know your source. Unfortunately, because the medical cannabis industry is largely unregulated, charlatans selling bogus products definitely exist. You should not have to pay exorbitant amounts of money for any cannabis product that you buy from regulated pharmacies or online. Also, make quality a priority for you. Be sure that your product comes from an organic source and that you know that the plant has not been grown or processed using pesticides.best place to buy cannabis online
  3. Stick with natural cannabis products. Synthetically-produced cannabinoids such as Marinol are commercially available. However, anecdotal evidence has found that these do not work as efficiently as natural substances do.
  4. Work with a professional healthcare provider trained in cannabinoid therapy. These professionals are out there in increasing numbers, especially in states where the medical cannabis industry is well established or growing, such as California and Colorado. Reach out to a patient advocate group online if no qualified professionals are in your area.
  5. Make cannabis therapy an important part of your overall cancer-healing toolbox. A well-rounded naturally-based cancer healing protocol involves working with the body’s own healing mechanisms through a variety of means. For you, this may mean changes to your diet and lifestyle, reducing stress, getting quality sleep, moving your body, intense detoxing protocols, and using other supplements and proven natural methods in addition to the powerful healing power of cannabis.best place to buy cannabis online

There has been a lot of interest in cannabinoids. Delta-9-tetrahydrocannabidiol and cannabidiol have been studied to see if they could have any role in the treatment of cancer.

Most of the scientific research has been done in a laboratory. Scientists have found that different cannabinoids can:

  • cause a cell to die
  • stop cells from dividing
  • stop cells from developing new blood vessels.

But they have also found that cannabinoids can:

  • damage important blood vessels
  • in some situations, encourage cancer cells to grow.

Some studies have looked at whether using cannabis may increase the risk of developing cancer. These have produced different results. Some research has shown that using cannabis may protect against cancer. But other studies have shown an increased risk of cancer.

It is still unclear whether using cannabis has any anti-cancer effects. But there is some evidence that the chemicals in cannabis might help with symptoms such as nausea and pain. For example, some drugs that have been developed using the chemicals in cannabis have been effective in treating sickness caused by chemotherapy, or improving a person’s appetite. But these studies have had mixed results when used in clinical trials. Because of the mixed results, the general feeling of experts is that there needs to be more research into the chemicals found in cannabis and their possible benefit.best place to buy cannabis online without prescription.buy weed online safe without a medical card

Cannabis vs Brain cancer

New Research Confirms Cannabis Kills Brain Cancer, NOT Your Brain

Some might say it’s too good to be true. Does cannabis really fight brain cancer? Research of the past two decades suggests that it does.

Some might think that it’s too good to be true. Does cannabis really kill brain cancer cells? Clinical trials on humans are awaiting results, but recent research gives hope. Scientists have been testing THC as a natural tumor-killer for nearly two decades. Their findings will take you by surprise.

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The potential therapeutic effects of cannabis have gained a lot of attention in recent years, from both brain tumour patients and within the media.buy weed online safe without a medical cardTwo of Brain Tumour Research’s Member Charities have now joined forces to launch a study into the clinical effects of cannabidiol (CBD), the non-psychoactive ingredient in cannabis. The research, builds upon previous research in this area and will be conducted by the Children’s Brain Tumour Research Centre at the University of Nottingham, and is being co-funded by the Astro Brain Tumour Fund and other brain tumour foundations.

The calls for research into the effectiveness of cannabis-based treatments have not just been prompted by a growing number of brain tumour patients and researchers, but also by Parliamentarians.

In the run-up to the General Election, Baroness Meacher, Co-Chair of the All-Party Parliamentary Group on Drug Policy Reform has called for a relaxation of the rules around cannabis-based medicines. It has been noted how cannabis can also provide symptomatic relief to patients with various conditions, and it is licensed for the treatment of multiple sclerosis.

We have analysed the evidence for the use of cannabis as a potential treatment for brain tumours.buy weed online safe without a medical card

A group of Spanish researchers has been searching for cannabis-based cancertreatments for nearly two decades. The team is from the Complutense University of Madrid. Thus far, some of their experiments have been nothing short of miraculous.

The team, lead by Professors Guillermo Velasco and Manuel Guzman, are testing cannabinoid treatment’s ability to kill glioma cells. Gliomas make up 80% of all malignant brain cancers. In fact, it’s one of the most aggressive forms of cancer out there. Once a glioblastoma reaches stage 4, the average life expectancy is less than two years. This is with surgery and traditional treatments like radiation and chemotherapy.buy weed online safe without a medical card

With such grim diagnoses, developing effective treatment alternatives is an absolute must. Fortunately, the Madrid team is finding success where few thought success was possible.

Back in the early 2000s, Dr. Velasco and his team had a breakthrough. They applied extracted THC to glioblastoma cells cultured outside of the body. THC is the main psychoactive compound in cannabis. What happened shocked researchers around the world. The tumor cells stopped growing. Later on, tumor cells actually began to die.

But, how? Turns out, THC kills glioblastoma cells in a couple of ways. THC and other cannabinoids cut off the tumor’s blood supply and cause cancer cells to commit suicide.best place to buy weed online

Death by starvation

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In 2004, researchers found that cannabis alters genes that produce a compound known as VEGF. VEGF stands for Vascular Endothelial Growth Factor. This compound helps grow new blood vessels. When cancer cells begin to grow large, they need to start creating their own blood vessels.buy weed online safe without a medical card

The Spanish researchers treated mice and two human brain cancer patients with cannabinoid medicines. In both models, VEGF was reduced, limiting the tumors’ blood supply. This finding was truly groundbreaking. Coupled with additional evidence that cannabis can slow the growth of tumors, the case for cannabinoid medicines just kept getting stronger.best place to buy weed online safe

Cell sucide

Another major discovery that cannabinoids may actually kill cancer cells. Compounds in the herb prevented tumors from growing, began to starve them by cutting off the blood supply, and eventually cause cancer cells to self-destruct. This self-destruction is a form of what scientists called “programmed cell death”.buy weed online safe without a medical card

Programmed cell death occurs in two ways: apoptosis and autophagy. Both apoptosis and autophagy are normal for cells. When a cell becomes too old or damaged, the body uses these mechanisms to eliminate the rogue cell.

For some reason, cancer cells do not self-destruct. Rather, they continue to grow and grow, creating life-threatening tumors. In their investigations, the Spanish researchers found that THC caused cancer cells to “auto-digest themselves”, or undergo autophagy.

We actually disocvered a new mechanism by which cannabinoids activate a signalling pathway that involes what we call autophagy, which would be like the self-digestion of the cells. So, actually, when cannabinoids are binding to the cells, they trigger a cell-signalling mechanism.

One of the things they are activating is like a self-digestion of the cell that is leading to cancer cell death. – Dr. Velasco

The funny thing is, this cell death only happens to cancer cells. Normal cells in the body remain unharmed. This finding is interesting since back in 1998 the same group of researchers found that THC also triggers apoptosis in glioma cells as well. So, cannabinoids kill cancer cells by utilizing both mechanisms of programmed cell death.

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The “miracle baby”

Dr. William Courtney has made a name for himself as the cannabis-juicing doctor. A strong advocate for raw cannabis, he has helped patients overcome lupus, endometriosis, arthritis, and many other diseases through cannabis regimes. Yet, the case of his youngest patient is the most miraculous of all.

Dr. Courtney oversaw an eight-month-old baby’s recovery from brain cancer. While the parents and child remain unnamed for their privacy, brain scans show that a high-CBD cannabis oil was able to make this child’s brain tumor disappear.best place to buy cannabis online with overnight delivery

They were putting cannabinoid oil on the baby’s pacifier twice a day, increasing the dose… And within two months there was a dramatic reduction, enough that the pediatric oncologist allowed them to go ahead with not pursuing traditional therapy. – Courtney

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As a dietitian, Jermy Kigar has spent a lot of time in hospitals. Yet, one day he was surprised to find that he had become a patient at his own workplace. Kigar had gone into a patient’s room and collapsed. He was having a seizure. He woke up a while later in the emergency room.

The diagnosis? A Grade 4 astrocytoma in the cerebellum. Kigar had a very serious brain tumor. He almost immediately started chemotherapy and radiation. They caused hair loss and Kigar quickly began to develop severe side effects of the drugs, including Chron’s disease. Cannabis helped Kigar overcome these symptoms.

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After starting cannabis treatment, his tumor dropped from a grade 4 to a grade 2. He has increased his dose to a gram each day, in 90-day cycles. He eventually stopped taking his oral chemotherapy and now uses cannabis as his primary treatment. His tumor has been slowly decreasing with the use of CBD-rich cannabis oil.best place to buy cannabis online

 

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Marijuana which comes in the form dried leaves, flowers, stems and seeds. buy weed online safe. The Marijuana plant is often referred to as the hemp plant.buy marijuana online safe.buy weed online. The fibers of the hemp plant are used for clothes, rope, and paper. The active ingredients of the hemp plant are the cannabinoids which contains chemicals that are used as the psychoactive drug people refer to commonly as Marijuana.buy weed online. The cannabinoids can slightly vary from plant to plant. Two popular breeds of cannabinoids in plants are cannabis sativa or cannabis indica.buy weed online. These plants grow in warm climates throughout the world. Marijuana is referred to by many names, some of which include cannabis, weed, pot, dope, ganja, dank, and herb. The psychoactive drug is used for various medical and recreational reasons. Variation in drug preparation and storage can greatly affect its level of potency.buy weed online. Marijuana can contain up to several hundred active chemicals. Of these many chemicals, tetrahydrocannabinol (THC) is the one credited as having the greatest effect on the user.buy cannabis online.buy weed online.

buy weed online.There are many different methods of consuming and feeling the effects of marijuana. Most people who use cannabis grind up the dried leaves of the plant and smoke it by way of joint, pipe, bong, vaporizer. The active chemicals in marijuana can also be consumed through an edible.buy edibles online. An edible is any form of food that is infused with the extracted chemicals from marijuana.buy weed online.buy edibles online usa.buy weed online The increasing popularity of marijuana amongst those in the United States has brought about many creative ways to intake the drug. THC extract, a concentrated form of the active chemical that can be smoked or added to various foods and drinks, has become another admired and highly effective form of marijuana consumption.1 Along with the many ways to smoke marijuana, there are also many variations in plant breed. Two of the most notable types are Indica and Sativa. buy cannabis oil online safe.buy weed online

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Strains, or varied forms, of cannabis that are of the indica breed are known to cause a stronger “body-high.” Users describe this high as more of a “full-body sensation” with a “couch-lock” effect,buy weed online like having no desire to move from the comfortable position on the couch. buy weed online.

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buy weed online.For many people, part of the appeal of marijuana is its rumored aphrodisiac-like qualities.buy weed online.buy weed online. THC can elevate mood and arousal, as well as stimulate sexual activity.bu weed online safe. While this may be the case for many cannabis users, not all people who use this drug have such a positive reaction. Despite the fact that this substance has the ability to enhance mood and reduce inhibitions, much in the way that alcohol does, it may also have some undesired effects on a person’s libido. While some users feel that it greatly increases their sexual desire, others experience the opposite effect.buy weed online Many report having a substantially decreased sexual drive when “stoned” or “high.” Further, it can be difficult to arouse people under the influence.buy weed online. Many marijuana users find that they fall somewhere in between these two extremes; that is, they are sometimes aroused and other times disappointed with marijuana’s sexual side effects. buy cannabis online euroupe.buy weed online

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Users and their partners also experience a variety of reactions to using marijuana during intercourse. Some claim that it fosters a greater bond between partners, stating that marijuana facilitates a more beautiful, open connection.buy weed online.buy weed online However, buy weed online.some partners find that under the influence of cannabis they tend to lose focus or internalize their thoughts.buy weed online safe.as a result, they tend to emotionally distance their partners instead of bring them closer.buy weed online Europe.buy weed online One reason that some people may report a heightened sense of sexuality is that marijuana often distorts users’ sense of time, thus creating the illusion of prolonged arousal and orgasm.buy weed online Australia. Furthermore,buy weed online some studies suggest that there is an association of marijuana use with increased rates of high risk sexual behavior and sexually transmitted infections.buy weed online. best place to buy weed online. buyThis is due to marijuana’s ability to decrease inhibitions and make users less likely to use protection during intercourse. When using marijuana,buy weed online consent for sexual activity may become unclear. Consent is seen a clear and enthusiastic “yes” and is especially important when drugs/intoxication are involved. It is advised to take precaution and use protection,buy weed online such as a condom, when engaging in any sexual activity and establish a clear and comfortable form of communication when using marijuana or any drug. buy marijuana online.buy weed online

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buy weed online.As mentioned above, marijuana has the ability to bring people closer together or farther apart, both physically and emotionally.buy vape pens online. The use of marijuana should be discussed openly and honestly between partners.buy weed online Communication is essential for the health of every relationship. If one is concerned that their partner is experiencing negative effects from marijuana, it is best that they communicate their concerns in a considerate manner. Each partner should come to a common understanding about the role that marijuana plays in their relationship and how it affects each partner in the relationship.buy vape pens online cheap and safe.For tips on communicating with your partner, check out this article on “Effective Communication.”online weed buy weed online

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Marijuana has the ability to affect both male and female fertility. However, since the drug is outlawed by most societies around the world, research on the effects of cannabis have been limited. buy weed online.However, there have been some studies conducted that produced noteworthy correlations between marijuana use and its impact on fertility as well as fetal development.buy weed online.buy weed online

A study conducted in 2015 by the Oxford University Press found that smoking marijuana more than once a week might lower a male’s sperm count by nearly a third.buy weed online. Specifically, the men who smoked marijuana more than once a week produced sperm counts that were 28% lower, on average, than those who smoked marijuana less frequently or not at all.buy weed online

Furthermore, the research suggests that while it is still unclear as to why males’ sperm count decreases,buy weed online it is possible that this decrease can be contributed to the THC interacting, and subsequently disrupting, certain receptors in the testes.buy weed onlineHowever, the researchers refrain from making the conclusion that the reduction in sperm count is solely due to the use of marijuana. They suggest that there may be other behavioral and lifestyle factors that can affect sperm count and hormonal levels,buy weed online which in turn may decrease fertility.buy weed online

In 2003, a study from the University of Buffalo found that smoking marijuana could make sperm less fertile, even if the female is the one who is using the drug. When females smoke marijuana, their reproductive fluids or vaginal secretions may contain the chemicals from cannabis.buy weed online. The research suggests that when a female smokes or ingests marijuana,buy weed online the THC is then present in the vagina, oviduct, and the uterus.buy weed online Even if a male has not smoked but the female has, his sperm may enter her body, come in contact with the THC in her system, and subsequently be altered by the THC/sperm interaction. buy weed online

The Alcohol and Drug Abuse Institute of the University of Washington suggests that marijuana use by females may affect their fertility by disrupting their menstrual cycle,buy weed online. which may result in fewer eggs being released. Furthermore, they conclude that THC has the ability to cross through the placental barrier and secrete into the breast milk of nursing mothers. buy weed online. Therefore, it is suggested that any pregnant or breastfeeding mother refrain from using marijuana.buy weed online. Furthermore, research shows that there may be major effects on the development and maturation of the fetal brain if a female uses marijuana during pregnancy. While these findings are not conclusive, they do point out the risks of using marijuana and its impact on both male and female fertility. buy weed online.

The use of marijuana and its effects on the mind, body, sex, relationships, and health are unique to every individual.buy weed online.While some claim that marijuana has a positive effect on their lives, others feel as though it affects their lives negatively. buy weed online. It is recommended that you discuss marijuana use with your doctor before experimenting with it. They may have insight as to how it will affect you and your body based on your medical history.buy weed online. SexInfo Online does not endorse the use of illegal drugs but promotes safety during the use or experimentation of any substance.buy weed online

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During the 1980s, several studies considered pot’s effects on lovemaking. The results were all over the map, from strongly sex-inhibiting to strongly sex-enhancing. The best report, based on interviews with 97 adults in Kansas City, showed that “over two-thirds reported increased sexual pleasure and satisfaction with marijuana use. best place to buy marijuana online safely. About half of both sexes also reported increased sexual desire while using marijuana. Emotional closeness and physical enjoyment of snuggling were also enhanced.” But one-third said the drug was not sex-enhancing, and half reported no increase in desire. [Weller, RA and JA Halikas, “Marijuana Use and Sexual Behavior. buy weed online

 

That was pretty much where things stood for 20 years.buy weed online.Then, in 2003, Canadian researchers interviewed 104 Toronto adults about their reactions to marijuana. Did it increase libido? One-quarter said it “often” or “always” did, 40 percent said “sometimes,” and one-third said it “seldom” or “never” enhanced their sexual desire. About half called the drug sex-enhancing, but half said it was not. buy marijuana online. One-third said sexual enhancement was a key reason they used weed, but half said sex played little, if any, role in their use of the drug.buy weed online safe and cheap

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In 2008, another Canadian team interviewed 41 adults. where can i buy marijuana online safe . About half said marijuana boosted their libidos, increased sensitivity to touch, and enhanced erotic pleasure.buy weed online saf.  But half said it did not. [Osborne GB and C Fogel. “Understanding the Motivations for Recreational Marijuana Use Among Canadians. buy weed online safe withou prescripton.

This range of findings is pharmacologically unique. The sexual effects of every other mood-altering drug–alcohol, amphetamines, antidepressants, cocaine, narcotics–are well-documented, fairly consistent, and not particularly controversial.buy weed online without a medical card. But oddly, marijuana’s sexual effects are highly unpredictable, from strongly sex-inhibiting to strongly sex-enhancing. Those who call it sex-inhibiting typically report that it pulls them deep inside themselves, so far inward that they lose their sense of connection to their partners.where can i buy weed onine safe. Meanwhile those who call marijuana sex-enhancing usually say that it boosts desire, adds to enjoyment of sensual touch. buy weed online cheap. helps them feel closer to their partner, and enhances overall sexual pleasure and satisfaction.

Unfortunately, all three of studies I mentioned involved small numbers of participants (97, 104, and 41). where to buy weed online safe without a medical card. Let’s correct that. How does marijuana affect you sexually? Is it sex-inhibiting? Sex-neutral? Or sex-enhancing?

Although survey studies have found that many guys report sexual benefits of marijuana use, such as increased sexual stamina, it is difficult to know what to make of findings like this. While the conclusion that marijuana helps guys last longer in bed is tempting, place to buy weed online safe.best we cannot rule out the possibility that this drug simply alters men’s perception of time. In other words, sex might seem to last longer when you’re high, but the actual amount of time you spend having sex might not really be any different from when you’re sober.

In the hope of providing a more definitive answer, biomedical researchers have begun to conduct more controlled research looking at the effect marijuana has on erectile functioning. Their scientific efforts reveal that, rather than helping erections, weed could potentially hurt them.

Animal studies have found that cannabis has an inhibitory effect on certain receptors inside the erectile tissue of the penis. buy cannabis online without prescription.We don’t have parallel research showing the same thing in humans (at least not yet) because of ethical and legal difficulties in conducting the research, but the animal findings suggest that marijuana is more of a sexual inhibitor than it is a sexual enhancer.

However, there are a few caveats.buy weed online.For one thing, researchers have long argued that dosage is a very important consideration when looking at the effects of this drug, just like it is with alcohol. If you consume marijuana or alcohol in small quantities, the inhibitory effects on sexual performance tend to be pretty minimal.bu cannabis online uk.  In fact, you may actually experience an overall performance boost with low doses due to these drugs lowering inhibitions and stimulating desire.buy cannabis online with descrete delivery.

In contrast, when drugs like marijuana and alcohol are consumed in larger quantities, erectile and other sexual problems (e.g., difficultly reaching orgasm) become much more likely.buy weed online.Consistent with the idea that higher doses of cannabis may be problematic, research has found that the prevalence of erectile dysfunction is three times as high for daily marijuana smokers compared to those who don’t use it at all.buy cannabis online safe

Beyond dose, there are at least two other things to keep in mind.buy marijuana online First, marijuana is not just one thing. There are different strains of cannabis that can affect the body in very different ways. One strain (indica) tends to more relaxing, while the other (sativa) tends to be more stimulating. Researchers haven’t yet looked at whether these cannabis strains impact sexual functioning in different ways, but it is worth exploring.buy marijuana online cheap

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Substantial evidence from animal research and a growing number of studies in humans indicate that marijuana exposure during development can cause long-term or possibly permanent adverse changes in the brain. Rats exposed to THC before birth, soon after birth, or during adolescence show notable problems with specific learning and memory tasks later in life.32–34 Cognitive impairments in adult rats exposed to THC during adolescence are associated with structural and functional changes in the hippocampus.Studies in rats also show that adolescent exposure to THC is associated with an altered reward system, increasing the likelihood that an animal will self-administer other drugs (e.g., heroin) when given an opportunity (see “Is marijuana a gateway drug?”).

Imaging studies of marijuana’s impact on brain structure in humans have shown conflicting results. Some studies suggest regular marijuana use in adolescence is associated with altered connectivity and reduced volume of specific brain regions involved in a broad range of executive functions such as memory, learning, and impulse control compared to people who do not use.38,39 Other studies have not found significant structural differences between the brains of people who do and do not use the drug.40

Several studies, including two large longitudinal studies, suggest that marijuana use can cause functional impairment in cognitive abilities but that the degree and/or duration of the impairment depends on the age when a person began using and how much and how long he or she used.41

Among nearly 4,000 young adults in the Coronary Artery Risk Development in Young Adults study tracked over a 25-year period until mid-adulthood, cumulative lifetime exposure to marijuana was associated with lower scores on a test of verbal memory but did not affect other cognitive abilities such as processing speed or executive function. The effect was sizeable and significant even after eliminating those involved with current use and after adjusting for confounding factors such as demographic factors, other drug and alcohol use, and other psychiatric conditions such as depression.

A large longitudinal study in New Zealand found that persistent marijuana use disorder with frequent use starting in adolescence was associated with a loss of an average of 6 or up to 8 IQ points measured in mid-adulthood.43 Significantly, in that study, those who used marijuana heavily as teenagers and quit using as adults did not recover the lost IQ points. People who only began using marijuana heavily in adulthood did not lose IQ points. These results suggest that marijuana has its strongest long-term impact on young people whose brains are still busy building new connections and maturing in other ways. The endocannabinoid system is known to play an important role in the proper formation of synapses (the connections between neurons) during early brain development, and a similar role has been proposed for the refinement of neural connections during adolescence. If the long-term effects of marijuana use on cognitive functioning or IQ are upheld by future research, this may be one avenue by which marijuana use during adolescence produces its long-term effects.

However, recent results from two prospective longitudinal twin studies did not support a causal relationship between marijuana use and IQ loss. Those who used marijuana did show a significant decline in verbal ability (equivalent to 4 IQ points) and in general knowledge between the preteen years (ages 9 to 12, before use) and late adolescence/early adulthood (ages 17 to 20). However, at the start of the study, those who would use in the future already had lower scores on these measures than those who would not use in the future, and no predictable difference was found between twins when one used marijuana and one did not. This suggests that observed IQ declines, at least across adolescence, may be caused by shared familial factors (e.g., genetics, family environment), not by marijuana use itself.45 It should be noted, though, that these studies were shorter in duration than the New Zealand study and did not explore the impact of the dose of marijuana (i.e., heavy use) or the development of a cannabis use disorder; this may have masked a dose- or diagnosis-dependent effect.

The ability to draw definitive conclusions about marijuana’s long-term impact on the human brain from past studies is often limited by the fact that study participants use multiple substances, and there is often limited data about the participants’ health or mental functioning prior to the study. Over the next decade, the National Institutes of Health is funding the Adolescent Brain Cognitive Development (ABCD) study—a major longitudinal study that will track a large sample of young Americans from late childhood (before first use of drugs) to early adulthood. The study will use neuroimaging and other advanced tools to clarify precisely how and to what extent marijuana and other substances, alone and in combination, affect adolescent brain development.

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